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Tirucallane Triterpenoid Saponins from Munronia delavayi Franch
Author(s) -
Cai XiangHai,
Du ZhiZhi,
Luo XiaoDong
Publication year - 2007
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200790205
Subject(s) - chemistry , triterpenoid , stereochemistry , triterpenoid saponin , saponin , medicine , alternative medicine , pathology
Four new tirucallane triterpenoid saponins, named munronosides I–IV ( 2 – 5 ), along with three known triterpenoids, sapelin B ( 1 ), melianodiol, and (3 β )‐22,23‐epoxytirucall‐7‐ene‐3,24,25‐triol, were isolated from the EtOH extract of the whole plants of Munronia delavayi Franch by chromatographic methods. On the basis of spectroscopic evidences, the structures of 2 – 5 were elucidated as (20 S ,23 R ,24 S )‐21,25‐epoxy‐29‐{{ O ‐ β ‐d‐ glucopyranosyl‐(1→3)‐ O‐ [ α ‐l‐ rhamnopyranosyl‐(1→6)]‐ β ‐d‐ glucopyranosyl}oxy}‐23,24‐dihydroxytirucall‐7‐ene‐3,21‐dione ( 2 ), (3 β ,20 S ,23 R ,24 S )‐21,25‐epoxy‐29‐{{ O ‐ β ‐d‐ glucopyranosyl‐(1→3)‐ O‐ [ α ‐l‐ rhamnopyranosyl‐(1→6)]‐ β ‐d‐ glucopyranosyl}oxy}‐3,23,24‐trihydroxytirucall‐7‐en‐21‐one ( 3 ), (20 S ,23 R ,24 S )‐24‐(acetyloxy)‐21,25‐epoxy‐29‐{{ O ‐ β ‐d‐ glucopyranosyl‐(1→3)‐ O‐ [ α ‐l‐ rhamnopyranosyl‐(1→6)]‐ β ‐d‐ glucopyranosyl}oxy}‐23‐hydroxytirucall‐7‐ene‐3,21‐dione ( 4 ), and (3 β ,20 S ,23 R ,24 S )‐24‐(acetyloxy)‐21,25‐epoxy‐29‐{{ O ‐ β ‐d‐ glucopyranosyl‐(1→3)‐ O‐ [ α ‐l‐ rhamnopyranosyl‐(1→6)]‐ β ‐d‐ glucopyranosyl}oxy}‐3,23‐dihydroxytirucall‐7‐en‐21‐one ( 5 ).