Synthesis and Transformation of Methyl 2‐(6‐Hydroxy‐2‐phenylpyrimidin‐4‐yl)acetate: Simple Preparation of Pyrimidines with Heterocyclic Substituents | Zendy

Bevk David | Zendy; Grošelj Uroš | Zendy; Meden Anton | Zendy; Svete Jurij | Zendy; Stanovnik Branko | Zendy

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Synthesis and Transformation of Methyl 2‐(6‐Hydroxy‐2‐phenylpyrimidin‐4‐yl)acetate: Simple Preparation of Pyrimidines with Heterocyclic Substituents

Author(s) -

Bevk David,

Grošelj Uroš,

Meden Anton,

Svete Jurij,

Stanovnik Branko

Publication year - 2007

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200790182

Subject(s) - chemistry , condensation , transformation (genetics) , simple (philosophy) , organic chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry , biochemistry , physics , philosophy , epistemology , gene , thermodynamics

A simple and efficient synthesis of four new substituted pyrimidines, compounds 9a – d , from the title compound 3 is described. Conversion of 3 to methyl ( E )‐3‐(dimethylamino)‐2‐(6‐methoxy‐2‐phenylpyrimidin‐4‐yl)prop‐2‐enoate ( 4 ), followed by condensation with various dinucleophiles according to the ‘enaminone methodology’, afforded the target compounds 9 in medium‐to‐good yields.

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