Premium
Chiral Recognition of Zolmitriptan by Modified Cyclodextrins
Author(s) -
Kumar Vydyula Pavan,
Kumar Perepogu Arun,
Suryanarayana Iragavarapu,
Nageswar Yadavalli Venkata Durga,
Rao Kakulapati Rama
Publication year - 2007
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200790176
Subject(s) - chemistry , enantiomer , zolmitriptan , cyclodextrin , selectivity , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , biochemistry , receptor , sumatriptan , agonist
The two pyrrolidinylidenesulfamido‐modified β ‐cyclodextrins ( β ‐CDs) 3 and 4 were prepared and studied for chiral discrimination of the enantiomers ( R )‐ and ( S )‐ 1 of zolmitriptan. The pyrrolidinylidenesulfamido spacer improved the chiral discrimination and binding abilities of these modified cyclodextrins. The hosts 3 and 4 showed higher selectivity for ( S )‐ 1 . The association constants ( Table ) and enantioselectivity factors were calculated for the complexes of ( R )‐ and ( S )‐ 1 with the β ‐CDs 2 – 4 . The formation of host⋅guest complexes was confirmed by 1 H‐NMR studies.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom