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Cytotoxic Withaphysalins from Physalis minima
Author(s) -
Ma Lei,
Gan XianWen,
He QingPing,
Bai HaiYun,
Arfan Mohammad,
Lou FengChang,
Hu LiHong
Publication year - 2007
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200790143
Subject(s) - chemistry , cytotoxic t cell , physalis , stereochemistry , cell culture , withanolide , cancer , cancer research , biochemistry , in vitro , botany , pathology , genetics , biology , medicine , alternative medicine , withania somnifera
Abstract A novel withanolide, withaphysalin P ( 1 ) with a nine‐membered ring, and six other new withaphysalins, 2 – 7 , together with the three known withaphysalins 8 – 10 were isolated from Physalis minima L. The structures were deduced by means of spectroscopic analyses, and that of withaphysalin P ( 1 ) was confirmed by a single‐crystal X‐ray diffraction analysis. Plausible biosynthetic pathways were postulated ( Scheme 1 ). All compounds were tested for their antiproliferative activities toward the human colorectal‐carcinoma HCT‐116 cells and human nonsmall‐cell lung‐cancer NCI‐H460 cells ( Table 4 ). Compounds 1 – 3, 7 – 10, 7a , and 7b displayed moderate cytotoxic activity against the two human cancer cell lines.