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New Sesterterpenoids from the Marine Sponge Phyllospongia papyracea
Author(s) -
Lan WenJian,
Li HouJin
Publication year - 2007
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200790121
Subject(s) - chemistry , sponge , cancer cell lines , stereochemistry , high resolution , cancer cell , cancer , botany , medicine , remote sensing , geology , biology
Chemical investigation of an extract of the marine sponge Phyllospongia papyracea , collected from the South China Sea, led to the isolation and identification of three new scalarane‐type sesterterpenoids, compounds 1 – 3 . Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR as well as high‐resolution ESI‐MS experiments. (12 α ,16 β )‐12‐Acetoxy‐16‐hydroxy‐20,24‐dimethyl‐25‐norscalar‐17‐en‐24‐one ( 1 ) was cytotoxic against the leukemia P388 cancer cell line, with an IC 50 value of 5 μg/ml.
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