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Access to Paullone Analogues by Intramolecular Heck Reaction
Author(s) -
Joucla Lionel,
Popowycz Florence,
Lozach Olivier,
Meijer Laurent,
Joseph Benoît
Publication year - 2007
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200790076
Subject(s) - chemistry , intramolecular force , tricyclic , heck reaction , ring (chemistry) , derivative (finance) , stereochemistry , combinatorial chemistry , sulfur , catalysis , organic chemistry , palladium , financial economics , economics
The syntheses of paullone ( 1a ) and three paullone derivatives, including a sulfur analogue ( 2a ), a tricyclic derivative ( 2b ), and a ring‐enlarged variant ( 2c ), are described, Pd‐catalyzed intramolecular Heck reaction being the key step. The kinase‐inhibitory properties of the novel paullone analogues were investigated.