Optimization of Glycosylation Reactions in a Microreactor | Zendy

Geyer Karolin | Zendy; Seeberger Peter H. | Zendy

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Optimization of Glycosylation Reactions in a Microreactor

Author(s) -

Geyer Karolin,

Seeberger Peter H.

Publication year - 2007

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200790046

Subject(s) - microreactor , chemistry , glycosylation , glycosyl , reaction conditions , solvent , anomer , combinatorial chemistry , organic chemistry , catalysis , biochemistry

Glycosylations are notoriously difficult reactions that require extensive optimization regarding the type of anomeric leaving group, solvent, reaction temperature, and reaction time. Described is the use of a silicon‐based microreactor to screen reaction conditions and to scale‐up synthetic procedures. For the first time, glycosyl phosphates were employed in a microreactor. The optimized reaction conditions were successfully transferred to a batch process.

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