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Optimization of Glycosylation Reactions in a Microreactor
Author(s) -
Geyer Karolin,
Seeberger Peter H.
Publication year - 2007
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200790046
Subject(s) - microreactor , chemistry , glycosylation , glycosyl , reaction conditions , solvent , anomer , combinatorial chemistry , organic chemistry , catalysis , biochemistry
Glycosylations are notoriously difficult reactions that require extensive optimization regarding the type of anomeric leaving group, solvent, reaction temperature, and reaction time. Described is the use of a silicon‐based microreactor to screen reaction conditions and to scale‐up synthetic procedures. For the first time, glycosyl phosphates were employed in a microreactor. The optimized reaction conditions were successfully transferred to a batch process.