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Efficient Synthesis of Trialkyl 3‐Phenylbuta‐1,3‐diene‐1,2,4‐tricarboxylates by a Novel One‐Pot Multicomponent Reaction
Author(s) -
Yavari Issa,
Moradi Loghman,
MokhtarporyaniSanandej Ako,
Mirzaei Anvar
Publication year - 2007
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200790045
Subject(s) - chemistry , diene , alkyl , medicinal chemistry , organic chemistry , combinatorial chemistry , stereochemistry , natural rubber
Alkyl 2‐nitroacetates 2 react with alkyl phenylpropiolates 1 in the presence of Ph 3 P in a mechanistically novel reaction to afford trialkyl 3‐phenylbuta‐1,3‐diene‐1,2,4‐tricarboxylates in yields of 60–80% under neutral conditions.