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Novel Triterpenoids from Microtropis triflora with Antitumor Activities
Author(s) -
Wang KuiWu,
Zhang Hong,
Pan YuanJiang
Publication year - 2007
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200790031
Subject(s) - chemistry , triterpenoid , hela , terpene , stereochemistry , cervical carcinoma , biochemistry , cell , cancer , cervical cancer , medicine
Two unprecedented norfriedelane‐type triterpenoids, triflora lactone ( 1 ) and triptocalline B ( 2 ), were isolated from the MeOH extract of the stalks of Microtropis triflora Merr . et Freem ., together with five known compounds ( 3 – 7 ). Their structures were elucidated on the basis of spectroscopic and mass‐spectrometric data ( Tables 1 and 2 ). The new compounds were found to be cytotoxic against human cervical squamous carcinoma (Hela) cells, with IC 50 values of 21.6 and 17.6 μg/ml, respectively.