Novel Triterpenoids from  Microtropis triflora  with Antitumor Activities | Zendy

Wang KuiWu | Zendy; Zhang Hong | Zendy; Pan YuanJiang | Zendy

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Novel Triterpenoids from Microtropis triflora with Antitumor Activities

Author(s) -

Wang KuiWu,

Zhang Hong,

Pan YuanJiang

Publication year - 2007

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200790031

Subject(s) - chemistry , triterpenoid , hela , terpene , stereochemistry , cervical carcinoma , biochemistry , cell , cancer , cervical cancer , medicine

Two unprecedented norfriedelane‐type triterpenoids, triflora lactone ( 1 ) and triptocalline B ( 2 ), were isolated from the MeOH extract of the stalks of Microtropis triflora Merr . et Freem ., together with five known compounds ( 3 – 7 ). Their structures were elucidated on the basis of spectroscopic and mass‐spectrometric data ( Tables 1 and 2 ). The new compounds were found to be cytotoxic against human cervical squamous carcinoma (Hela) cells, with IC 50 values of 21.6 and 17.6 μg/ml, respectively.

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