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Triterpenoid Saponins from the Spikes of Prunella vulgaris
Author(s) -
Gu XiaoJie,
Li YouBin,
Li Ping,
Qian ShiHui,
Zhang JianFeng
Publication year - 2007
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200790023
Subject(s) - oleanane , triterpenoid , chemistry , prunella vulgaris , stereochemistry , terpene , triterpenoid saponin , triterpene , saponin , traditional chinese medicine , medicine , alternative medicine , pathology
Three new oleanane‐skeleton triterpenoid saponins, 3 β ,4 β ,16 α ‐17‐carboxy‐16,24‐dihydroxy‐28‐norolean‐12‐en‐3‐yl 4‐ O‐β ‐ D ‐xylopyranosyl‐ β ‐ D ‐glucopyranosiduronic acid ( 1 ), (3 β ,4 β ,16 α )‐17‐carboxy‐16,24‐dihydroxy‐28‐norolean‐12‐en‐3‐yl β ‐ D ‐glucopyranosiduronic acid methyl ester ( 2 ), and (3 β ,4 β )‐24‐hydroxy‐16‐oxo‐28‐norolean‐12‐en‐3‐yl 4‐ O‐β ‐ D ‐xylopyranosyl‐ β ‐ D ‐glucopyranosiduronic acid ( 3 ), together with eight known constituents, i.e. , the oleanane‐type triterpenoids 4 – 6 , and the ursane‐type triterpenoids 7 – 11 , were isolated from the spikes of Prunella vulgaris. The new structures were established by means of detailed spectroscopic analysis (IR, HR‐ESI‐MS, 1D‐ and 2D‐NMR experiments). Compounds 1 – 3 were tested for their inhibition activity against the growth of tumor cell lines; only compound 3 displayed marginal inhibition activity.