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Sesquiterpene Lactones from Anthemis melanolepis
Author(s) -
Saroglou Vasiliki,
Karioti Anastasia,
Heilmann Jörg,
Kypriotakis Zacharias,
Skaltsa Helen
Publication year - 2007
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200790012
Subject(s) - sesquiterpene , chemistry , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , heteronuclear single quantum coherence spectroscopy , sesquiterpene lactone , terpene
Abstract From the aerial parts of A. melanolepis , two new sesquiterpene lactones, melanolepin B ( = 1 α ,4 β ,8 α ‐trihydroxyeudesm‐11(13)‐en‐12,6 α ‐olide; 1 ) and melanolepin C (= 1 α ,10 β ‐epoxy‐8 β ‐hydroxygermacra‐4(15),11(13)‐dien‐12,6 α ‐olide; 2 ), were isolated, together with four known compounds, desacetyllaurenobiolide, dentatin A, taraxasterol, and (3 S ,5 R )‐loliolide. Compound 1 was found to have the rare cis ‐fused eudesmane skeleton. The structures of the isolated compounds were established by means of NMR ( 1 H, 1 H‐COSY, 1 H, 13 C‐HSQC, HMBC, NOESY) and MS analyses.