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Synthesis of β ‐Chlorohydrins in Water
Author(s) -
Das Biswanath,
Venkateswarlu Katta,
Krishnaiah Maddeboina
Publication year - 2007
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200790008
Subject(s) - chemistry , cyanuric chloride , morpholine , stereoselectivity , ring (chemistry) , transformation (genetics) , triazine , medicinal chemistry , organic chemistry , stereochemistry , biochemistry , catalysis , gene
2,4,6‐Trichloro‐1,3,5‐triazine (TCT, cyanuric chloride) was found to mediate the regio‐ and stereoselective ring opening of epoxides in H 2 O in the presence of morpholine at room temperature to afford the corresponding β ‐chlorohydrins in excellent yields ( Table ). The transformation is very simple, fast, efficient, and ecologically beneficial.
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