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Facile One‐Pot Multicomponent Synthesis of β ‐Acetamido Ketones with Amberlyst‐15 as Heterogeneous Catalyst
Author(s) -
Das Biswanath,
Reddy Kongara Ravinder
Publication year - 2006
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200690279
Subject(s) - chemistry , catalysis , aldehyde , acetonitrile , ketone , organic chemistry , heterogeneous catalysis , acetyl chloride , chloride , combinatorial chemistry
The one‐pot multicomponent coupling of an aromatic aldehyde, an enolizable ketone or keto ester, acetonitrile, and acetyl chloride at room temperature in the presence of Amberlyst‐15 as catalyst affords β ‐acetamido ketones in high yields. The inexpensive catalyst works under heterogeneous conditions and can be readily reused.