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Antioxidant and Antiradical Activity of Hydroxy‐Substituted 4‐Thiaflavanes
Author(s) -
Amorati Riccardo,
Fumo Maria Grazia,
Pedulli Gian Franco,
Menichetti Stefano,
Pagliuca Chiara,
Viglianisi Caterina
Publication year - 2006
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200690226
Subject(s) - chemistry , autoxidation , cumene , antioxidant , dpph , styrene , organic chemistry , oxidation state , medicinal chemistry , stereochemistry , benzene , catalysis , copolymer , polymer
The antioxidant activities of several hydroxy‐substituted 4‐thiaflavanes, compounds 1 – 3 , were determined by measuring their ability of inhibiting the autoxidation of styrene or cumene. On this basis, the role played by the number and position of OH groups and by the oxidation state of the S‐atom was quantified and rationalized. With these data, it should be possible to optimize the structural features of these ‘double‐faced’ antioxidants for structureactivity‐relationship studies. A comparison between the kinetic data ( k inh ) reported in this paper and the previously reported values of the antiradical activities ( SC 50 ), measured by the DPPH . bleaching method, for 1 – 3 is made ( Table ).