New Dammarane Monodesmosides from the Acidic Deglycosylation of Notoginseng‐Leaf Saponins

Three new dammarane monodesmosides, named notoginsenosides Ft 1 ( 1 ), Ft 2 ( 2 ), and Ft 3 ( 3 ), together with three known ginsenosides, were obtained from a mild acidic hydrolysis of the saponins from notoginseng ( Panax notoginseng ( Burk .) F. H. Chen ) leaves. Their structures were elucidated to be (3 β ,12 β ,20 R )‐12,20‐dihydroxydammar‐24‐en‐3‐yl O‐β ‐ D ‐xylopyranosyl‐(1 → 2)‐ O‐β ‐ D ‐glucopyranosyl‐(1 → 2)‐ β ‐ D ‐glucopyranoside ( 1 ), (3 β ,12 β )‐12,20,25‐trihydroxydammaran‐3‐yl O‐β ‐ D ‐xylopyranosyl‐(1 → 2)‐ O‐β ‐ D ‐glucopyranosyl‐(1 → 2)‐ β ‐ D ‐glucopyranoside ( 2 ), and (3 β ,12 β ,24 ξ )‐12,20,24‐trihydroxydammar‐25‐en‐3‐yl O‐β ‐ D ‐xylopyranosyl‐(1 → 2)‐ O‐β ‐ D ‐glucopyranosyl‐(1 → 2)‐ β ‐ D ‐glucopyranoside ( 3 ), by means of spectroscopic evidences. The known ginsenosides Rh 2 and Rg 3 4 – 6 were obtained as the major products from this acidic deglycosylation.