Synthetic Studies on Coenzyme Q 10 . Part 2 | Zendy

Dai HuiFang | Zendy; Chen FenEr | Zendy; Yu XiongJie | Zendy

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Synthetic Studies on Coenzyme Q 10 . Part 2

Author(s) -

Dai HuiFang,

Chen FenEr,

Yu XiongJie

Publication year - 2006

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200690130

Subject(s) - coenzyme q10 , chemistry , cofactor , alcohol , combinatorial chemistry , stereochemistry , total synthesis , coenzyme q – cytochrome c reductase , organic chemistry , biochemistry , enzyme , cytochrome c , mitochondrion

An improved route to coenzyme Q 10 ( 1 ) starting from commercially available coenzyme Q 1 is described. The key steps in this synthesis are the SeO 2 ‐mediated oxidation of the protected isoprenylhydroquinone 3 into the ( E )‐allyl alcohol 5 without the formation of undesired stereoisomer and the one‐pot reductive elimination of the phenylsulfonyl and dibenzyl groups in 7 by using naphthalenyllithium.

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