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Synthetic Studies on Coenzyme Q 10 . Part 2
Author(s) -
Dai HuiFang,
Chen FenEr,
Yu XiongJie
Publication year - 2006
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200690130
Subject(s) - coenzyme q10 , chemistry , cofactor , alcohol , combinatorial chemistry , stereochemistry , total synthesis , coenzyme q – cytochrome c reductase , organic chemistry , biochemistry , enzyme , cytochrome c , mitochondrion
An improved route to coenzyme Q 10 ( 1 ) starting from commercially available coenzyme Q 1 is described. The key steps in this synthesis are the SeO 2 ‐mediated oxidation of the protected isoprenylhydroquinone 3 into the ( E )‐allyl alcohol 5 without the formation of undesired stereoisomer and the one‐pot reductive elimination of the phenylsulfonyl and dibenzyl groups in 7 by using naphthalenyllithium.