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Synthesis of Highly Functionalized γ ‐Lactones via 1,5‐Electrocyclic Ring Closure
Author(s) -
Anaç Olcay,
Güngör F. Şeyma,
Merey Gökçe
Publication year - 2006
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200690120
Subject(s) - chemistry , ring (chemistry) , electrocyclic reaction , closure (psychology) , conjugated system , catalysis , combinatorial chemistry , lactone , organic chemistry , economics , market economy , polymer
We have investigated 1,5‐electrocyclic ring‐closure reactions of conjugated esters with dimethyl diazomalonate in the presence of [Cu(acac) 2 ] as catalyst. Our new protocol offers an easy entry to various polyfunctionalized γ ‐lactones in high yields. Their subsequent derivatives may be used as valuable intermediates, especially in the synthesis of natural products and their analogues.