One‐Pot Three‐Component Synthesis of Highly Functionalized 2,3‐Dihydro‐1,3‐dioxo‐1 H ,5 H ‐pyrazolo[1,2‐ a ][1,2,4]triazoles | Zendy

Adib Mehdi | Zendy; Sayahi Mohammad Hosein | Zendy; Mahmoodi Niusha | Zendy; Bijanzadeh Hamid Reza | Zendy

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One‐Pot Three‐Component Synthesis of Highly Functionalized 2,3‐Dihydro‐1,3‐dioxo‐1 H ,5 H ‐pyrazolo[1,2‐ a ][1,2,4]triazoles

Author(s) -

Adib Mehdi,

Sayahi Mohammad Hosein,

Mahmoodi Niusha,

Bijanzadeh Hamid Reza

Publication year - 2006

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200690115

Subject(s) - chemistry , component (thermodynamics) , elemental analysis , combinatorial chemistry , proton nmr , medicinal chemistry , stereochemistry , organic chemistry , physics , thermodynamics

The reactive 1 : 1 zwitterionic intermediate formed by the addition of isocyanides to dialkyl acetylenedicarboxylates was trapped with 4‐arylurazoles to produce the highly functionalized pyrazolo[1,2‐ a ][1,2,4]triazoles 5 in good yields ( Table ). The structures of the products 5a – h were corroborated spectroscopically (IR, 1 H‐ and 13 C‐NMR), by EI‐MS, and elemental analysis. A possible mechanism for this reaction is proposed ( Scheme ).

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