Synthesis of 1,2‐Disubstituted Carbocyclic Nucleoside Analogues of Cytidine | Zendy

GonzálezMoa María José | Zendy; Besada Pedro | Zendy; Terán Carmen | Zendy; Santana Lourdes | Zendy; Uriarte Eugenio | Zendy; Viña Dolores | Zendy

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Synthesis of 1,2‐Disubstituted Carbocyclic Nucleoside Analogues of Cytidine

Author(s) -

GonzálezMoa María José,

Besada Pedro,

Terán Carmen,

Santana Lourdes,

Uriarte Eugenio,

Viña Dolores

Publication year - 2006

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200690099

Subject(s) - chemistry , aminolysis , pyrimidine , ring (chemistry) , cytidine , nucleophile , uracil , derivative (finance) , nucleoside , stereochemistry , sulfonyl , combinatorial chemistry , organic chemistry , dna , catalysis , biochemistry , alkyl , financial economics , economics , enzyme

The synthesis of new 1,2‐disubstituted, five‐ or six‐ring‐carbocyclic nucleoside analogues of cytidine, compounds 1 and 2a – d , are described. These compounds were obtained by aminolysis, starting from the corresponding uracil derivative, via nucleophilic displacement of a triazolyl ( Scheme 1 ) or a (2,4,6‐triisopropylphenyl)sulfonyl (TPS) group ( Scheme 2 ) at 4‐position of the pyrimidine ring.

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