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Terpenoids from Eupatorium fortunei Turcz
Author(s) -
Jiang HaiXia,
Li Ya,
Pan Jing,
Gao Kun
Publication year - 2006
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200690059
Subject(s) - chemistry , terpenoid , terpene , acetone , stereochemistry , human liver , in vitro , organic chemistry , biochemistry
Four new terpenoids, namely, rel‐ (1 R ,2 S ,3 R ,4 R ,6 S )‐ p ‐menthane‐1,2,3,6‐tetrol ( 1 ), rel‐ (1 R ,2 R ,3 R ,4 S ,6 S )‐ p ‐menthane‐1,2,3,6‐tetrol ( 2 ), 9‐hydroxythymol 3‐ O ‐angelate ( 3 ), and (3 β ,20 R )‐20‐hydroxylanost‐25‐en‐3‐yl palmitate ( 4 ), together with fourteen known compounds, were isolated from the AcOEt part of the MeOH extracts of Eupatorium fortunei. In addition, two other monoterpenoids, ‘acetone thymol‐8,9‐diyl ketal’ ( 19 ) and 8‐methoxy‐9‐hydroxythymol 3‐ O ‐angelate ( 20 ) were also obtained which were probably artifacts but have never been reported in the literature. The structures of the new compounds, including their relative configurations, were established by an extensive study of their spectral data, especially 1D‐ and 2D‐NMR. The cytotoxic activity of the new compounds against human hepatoma (SMMC‐7721), human leukemia (HL‐60), and human hepatocyte (LO 2 ) cells was investigated.