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Formation of Dimers of Some 2‐Substituted Indan‐1‐one Derivatives during Base‐Mediated Cross‐Aldol Condensation
Author(s) -
Narang Gaurav,
Jindal Dharam Paul,
Jit Birinder,
Bansal Ranju,
Potter Brian S.,
Palmer Rex A.
Publication year - 2006
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200690028
Subject(s) - chemistry , aldol condensation , aldol reaction , condensation , monomer , nucleophile , base (topology) , dimer , condensation reaction , resolution (logic) , stereochemistry , polymer chemistry , crystallography , medicinal chemistry , catalysis , organic chemistry , polymer , mathematical analysis , physics , mathematics , computer science , artificial intelligence , thermodynamics
Unexpected dimers of some 2‐substituted indan‐1‐one derivatives were isolated during aldol condensation of indan‐1‐one with various aldehydes in the presence of KOH (see Scheme ). Monomeric products, usually expected from aldol condensation, further underwent a base‐catalyzed nucleophilic addition reaction to their dimeric form in some cases. The structures of these dimers were characterized by using various spectral techniques and in one case, structural details were determined from a high‐resolution crystallographic analysis.