Synthesis and Properties of Oligonucleotides Containing 2,4‐Dihydroxycyclohexyl Nucleosides | Zendy

Bardiot Dorothée | Zendy; Rosemeyer Helmut | Zendy; Lescrinier Eveline | Zendy; Rozenski Jef | Zendy; Van Aerschot Arthur | Zendy; Herdewijn Piet | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis and Properties of Oligonucleotides Containing 2,4‐Dihydroxycyclohexyl Nucleosides

Author(s) -

Bardiot Dorothée,

Rosemeyer Helmut,

Lescrinier Eveline,

Rozenski Jef,

Van Aerschot Arthur,

Herdewijn Piet

Publication year - 2005

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200590258

Subject(s) - chemistry , oligonucleotide , uracil , nucleic acid , stereochemistry , combinatorial chemistry , oligonucleotide synthesis , base (topology) , nucleobase , dna , biochemistry , mathematical analysis , mathematics

Cyclohexyl nucleosides with an adenine and uracil base have been synthesized from 2‐azidocyclohexane‐1,5‐diol. The obtained racemic nucleosides were resolved using ( R )‐ O ‐methylmandelic acid. Short oligonucleotides were synthesized using phorphoramidite chemistry. However, these oligonucleotides do not show self‐hybridization, and duplexes are less stable than those of ribopyranosyl‐(4′ → 2′)‐oligonucleotides.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research