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Design and Synthesis of Novel Artemisinin‐Like Ozonides with Antischistosomal Activity
Author(s) -
Yang ZhongShun,
Wu WenMin,
Li Ying,
Wu YuLin
Publication year - 2005
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200590229
Subject(s) - artemisinin , chemistry , ozonolysis , combinatorial chemistry , natural product , in vivo , lactone , stereochemistry , organic chemistry , plasmodium falciparum , malaria , immunology , biology , microbiology and biotechnology
To develop new drugs for prevention and treatment of schistosomiasis, a series of novel artemisinin‐like ozonides 10 were synthesized via a facile three‐step procedure starting with the degraded product of artemisinin ( Scheme ). The Criegee ozonolysis reaction of the unsaturated lactone intermediates 14 is the key step which provided the target molecules 10 . The in vivo pharmacological results suggested that this type of artemisinin analogues exhibited moderate antischistosomal activity ( Table ).