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Multiflorane Triterpene Esters from the Seeds of Trichosanthes kirilowii
Author(s) -
Wu Tao,
Cheng XueMei,
Bligh S. W. Annie,
Chou GuiXin,
Wang ZhengTao,
Bashall Alan,
BranfordWhite Chris
Publication year - 2005
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200590202
Subject(s) - triterpene , chemistry , trichosanthes , stereochemistry , cytotoxicity , cucurbitaceae , traditional medicine , botany , biochemistry , in vitro , medicine , alternative medicine , pathology , traditional chinese medicine , biology
Two new multiflorane triterpene esters, (3 α ,7 β )‐3,7,29‐trihydroxymultiflor‐8‐ene‐3,29‐diyl dibenzoate ( 2 ) and (3 α )‐3,29‐dihydroxy‐7‐oxomultiflor‐8‐ene‐3,29‐diyl dibenzoate ( 3 ) have been isolated from the CHCl 3 extract of the seeds of Trichosanthes kirilowii , together with two known compounds, (3 α ,5 α ,22 E )‐24‐ethylcholesta‐7,22,25(27)‐trien‐3‐ol and darutigenol. The structures of the new compounds were elucidated on the basis of extensive NMR experiments, and by means of an X‐ray crystallographic analysis of 2 . A preliminary cytotoxicity assay showed that 2 and 3 are basically inactive against the K562 cell line.