Robust Synthesis and Crystal‐Structure Analysis of 7‐Cyano‐7‐deazaguanine (PreQ 0  Base) and 7‐(Aminomethyl)‐7‐deazaguanine (PreQ 1  Base) | Zendy

Klepper Florian | Zendy; Polborn Kurt | Zendy; Carell Thomas | Zendy

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Robust Synthesis and Crystal‐Structure Analysis of 7‐Cyano‐7‐deazaguanine (PreQ 0 Base) and 7‐(Aminomethyl)‐7‐deazaguanine (PreQ 1 Base)

Author(s) -

Klepper Florian,

Polborn Kurt,

Carell Thomas

Publication year - 2005

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200590201

Subject(s) - chemistry , base (topology) , nucleoside , crystal structure , base pair , transfer rna , crystal (programming language) , stereochemistry , rna , crystallography , dna , biochemistry , computer science , programming language , gene , mathematical analysis , mathematics

We describe robust and efficient synthetic methods for the synthesis of the preQ 0 and preQ 1 bases, which are the biosynthetic precursors of the hypermodified RNA nucleoside queuosine. The X‐ray crystal‐structure analysis of preQ 1 is also described.

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