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Robust Synthesis and Crystal‐Structure Analysis of 7‐Cyano‐7‐deazaguanine (PreQ 0 Base) and 7‐(Aminomethyl)‐7‐deazaguanine (PreQ 1 Base)
Author(s) -
Klepper Florian,
Polborn Kurt,
Carell Thomas
Publication year - 2005
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200590201
Subject(s) - chemistry , base (topology) , nucleoside , crystal structure , base pair , transfer rna , crystal (programming language) , stereochemistry , rna , crystallography , dna , biochemistry , computer science , programming language , gene , mathematical analysis , mathematics
We describe robust and efficient synthetic methods for the synthesis of the preQ 0 and preQ 1 bases, which are the biosynthetic precursors of the hypermodified RNA nucleoside queuosine. The X‐ray crystal‐structure analysis of preQ 1 is also described.