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Three New Indole Alkaloids from the Leaves of Alstonia scholaris
Author(s) -
Zhou Hua,
He HongPing,
Luo XiaoDong,
Wang YueHu,
Yang XianWen,
Di YingTong,
Hao XiaoJiang
Publication year - 2005
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200590186
Subject(s) - chemistry , indole test , hydroxymethyl , stereochemistry , apocynaceae , traditional medicine , medicine
Three new akuamillan‐type indole alkaloids, i.e. , 5‐methoxystrictamine (=methyl (5 β ,16 R ,19 E )‐5‐methoxyakuammilan‐17‐oate; 1 ), methyl (16 R ,19 E )‐1,2‐dihydro‐16‐(hydroxymethyl)‐5‐oxoakuammilan‐17‐oate ( 2 ), and methyl (2 β ,16 R ,19 E )‐4,5‐didehydro‐1,2‐dihydro‐2‐hydroxy‐16‐(hydroxymethyl)akuammilan‐4‐ium‐17‐oate chloride ( 3 ), have been isolated from the leaves of Alstonia scholaris , together with ten known compounds. Their structures were determined by spectroscopic means. None of the constituents showed significant cytotoxic activity towards WT cells.