Premium
Three New Cytotoxic ent‐ Kaurane Diterpenoids from Isodon weisiensis C. Y. Wu
Author(s) -
Ding Lan,
Zhang ZhangJing,
Liu GuoAn,
Yang DongJuan,
Guo GuoCong,
Wang Han,
Sun Kun
Publication year - 2005
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200590185
Subject(s) - chemistry , orthorhombic crystal system , stereochemistry , crystal structure , molecule , cancer cell lines , crystallography , cancer cell , organic chemistry , cancer , medicine
Three new cytotoxic ent‐ kaurane diterpenoids, (1 α ,7 α ,14 β )‐1,7,14‐trihydroxy‐ ent ‐kaur‐16‐en‐15,18‐dione ( 1 ), (1 α ,7 α ,14 β )‐1,7,14,18,20‐pentahydroxy‐ ent ‐kaur‐16‐en‐15‐one ( 2 ), and (3 β ,7 α ,14 β )‐3,7,14‐tris(acetyloxy)‐ ent ‐kaur‐16‐en‐15‐one ( 3 ), were isolated from Isodon weisiensis C. Y. Wu. Their structures were elucidated by spectroscopic methods, including 2D‐NMR techniques, and the crystal structure of 1 was determined by single‐crystal X‐ray‐diffraction analysis. The chosen crystal of 1 was orthorhombic, space group P 2 1 2 1 2 1 , and there were two molecules with little difference in bond length and bond angle in the least‐asymmetry unit. Compounds 1–3 showed significant cytotoxic activities against human‐cancer cell lines Bel‐7402 and HO‐8910.