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The Preparation of 1,2,3‐Trisubstituted Guanidines
Author(s) -
Katritzky Alan R.,
Khashab Niveen M.,
Bobrov Sergey
Publication year - 2005
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200590131
Subject(s) - benzotriazole , chemistry , reagent , methylene , combinatorial chemistry , organic chemistry
An operationally straightforward and efficient benzotriazole‐based method for the guanylation of diverse amines by use of the new reagent classes (bis‐benzotriazol‐1‐yl‐methylene)amines 13a – 13f and benzotriazole‐1‐carboxamidines 17a – 17i is described. The preparation is described for a variety of both acyclic and cyclic 1,2,3‐trisubstituted guanidines in high yields.
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