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Stereoselective Synthesis of Tetrahydrofuran Spiro‐ β ‐Lactams by Ru‐Catalyzed Metathesis of 7‐Oxabicyclo[2.2.1]heptenes
Author(s) -
Csákÿ Aurelio G.,
Medel Rocío,
Murcia M. Carmen,
Plumet Joaquín
Publication year - 2005
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200590111
Subject(s) - chemistry , tetrahydrofuran , metathesis , stereoselectivity , cycloaddition , catalysis , stereochemistry , organic chemistry , polymerization , polymer , solvent
A new method for the synthesis of spiro‐ β ‐lactams tethered to tetrahydrofuran rings is described. The procedure is based on Ru‐catalyzed metathesis sequences with oxanorbornene precursors easily obtained by the Staudinger [2+2] cycloaddition of related imines.