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Two Novel Olean Triterpenoids from Celastrus hypoleucus
Author(s) -
Wang Kuiwu,
Sun Hongxiang,
Wu Bin,
Pan Yuanjiang
Publication year - 2005
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200590094
Subject(s) - chemistry , triterpenoid , hela , cytotoxicity , palmitic acid , stereochemistry , terpene , organic chemistry , biochemistry , cell , fatty acid , in vitro
Two new triterpenoids, (3 β )‐olean‐12‐ene‐3,23‐diol ( 1 ) and (6 α )‐6‐hydroxyolean‐12‐en‐3‐one ( 2 ) were isolated from the MeOH extract of the stalks of Celastrus hypoleucus ( Oliv .) Warb ., together with the seven known compounds (3 β ,22 α )‐3,22‐dihydroxyolean‐12‐en‐29‐oic acid, β ‐amyrin and β ‐amyrin palmitate, wilforlide A, wilforilide B, palmitic acid, and β ‐sitosterol. Their structures were elucidated on the basis of spectroscopic data and, in the case of 2 , by X‐ray crystallography. Compound 1 showed moderate cytotoxicity against human cervical squamous carcinoma (Hela) cells.