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Modular Microreaction Systems for Homogeneously and Heterogeneously Catalyzed Chemical Synthesis
Author(s) -
Snyder Daniel A.,
Noti Christian,
Seeberger Peter H.,
Schael Frank,
Bieber Thomas,
Rimmel Guido,
Ehrfeld Wolfgang
Publication year - 2005
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490304
Subject(s) - modular design , chemistry , microreactor , exothermic reaction , nanotechnology , homogeneous , flow chemistry , chemical reaction , fine chemical , catalysis , organic chemistry , computer science , materials science , physics , thermodynamics , operating system
Abstract Until now, microreaction devices designed for a specific type of reaction were used mainly for highly exothermic, very fast reactions. Described is a modular microreaction system and its application to representative homogeneous and heterogeneous reactions important in organic synthesis. The modular microreaction system allows continuous flow processes to be optimized and employed effectively in the chemical laboratory. The modular microreaction systems proved also versatile for syntheses requiring moderate reaction times, thus extending their application to a large fraction of organic reactions. The use of the modular and cleanable microreaction systems to rapidly develop optimized reaction conditions provides an excellent basis for the development of many chemical transformations scalable from milligram to ton production quantities.