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New Clerodane Diterpenoids from Casearia membranacea
Author(s) -
Shen YaChing,
Lee Cheng Lin,
Khalil Ashraf Taha,
Cheng YuanBin,
Chien ChingTe,
Kuo YaoHaur
Publication year - 2005
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490297
Subject(s) - hela , chemistry , stereochemistry , carcinoma cell , terpene , terpenoid , bioassay , fractionation , cytotoxicity , cytotoxic t cell , biochemistry , in vitro , organic chemistry , ecology , biology
Bioassay‐guided fractionation of an AcOEt extract of Casearia membranacea resulted in the isolation of six new clerodane diterpenes, caseamembrins G–L ( 1 – 6 ). The structures of the new compounds, including their relative configurations, were established by an extensive study of their spectral data, especially 2D NMR. The cytotoxic activities of the isolated diterpenes against human oral epidermoid (KB), cervical epitheloid (Hela), and liver (Hep59T/VGH) carcinoma cell lines were investigated.