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Noncovalent Attachment of Nucleotides by FluorousFluorous Interactions: Application to a Simple Purification Principle for Synthetic DNA Fragments
Author(s) -
Beller Christian,
Bannwarth Willi
Publication year - 2005
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490291
Subject(s) - chemistry , dna , nucleotide , simple (philosophy) , combinatorial chemistry , non covalent interactions , molecule , organic chemistry , biochemistry , hydrogen bond , philosophy , epistemology , gene
We report a highly efficient noncovalent immobilization of DNA fragments on surfaces by fluorous fluorous interactions. The principle was applied to a simple and straightforward purification protocol for synthetic DNA. The method is completely compatible with standard solid‐phase synthesis of DNA.