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Immunosuppressive ent ‐Kaurene Diterpenoids from Isodon serra
Author(s) -
Zhao AiHua,
Zhang Yan,
Xu ZhaoHui,
Liu JianWen,
Jia Wei
Publication year - 2004
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490281
Subject(s) - chemistry , stereochemistry , terpene , diterpene , traditional medicine , medicine
Three new enmein‐type ent ‐kaurenoids, i.e. , the two pairs 1 and 2 of 20‐epimers and the (20 R )‐isomer 3 , besides the seven known diterpenoids 4 – 10 , were isolated from the aerial parts of Isodon serra. Their structures were elucidated by spectroscopic techniques and X‐ray diffraction. The immunosuppressive effect for T‐lymphocytes proliferation induced by Con A in BALB/c mouse was evaluated for the isolates 1 – 10 . They all displayed a remarkable inhibitory effect, with multi‐glycosides of Tripterygium wilfordii as positive reference substance ( Table 3 ).