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Efficient Coupling Reactions of Arylalkynes and Aldehydes Leading to the Synthesis of Enones
Author(s) -
Xu LiWen,
Li Lyi,
Xia ChunGu,
Zhao PeiQing
Publication year - 2004
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490276
Subject(s) - chemistry , organic chemistry , coupling reaction , ionic liquid , catalysis , coupling (piping) , transformation (genetics) , ionic bonding , combinatorial chemistry , ion , mechanical engineering , biochemistry , engineering , gene
Ionic liquids such as 1‐butyl‐3‐methyl‐1 H ‐imidazolium 4‐methylbenzenesulfonate (BmimOTs) and its 1‐ethyl analogue EmimOTs are novel effective and recyclable media for acid‐catalyzed coupling reactions of aromatic alkynes with aldehydes affording ( E )‐enones ( Scheme 1, Table ) with simple recovery and easy workup due to the absence of volatile organic solvents. This transformation avoids the use of moisture‐sensitive and heavy‐metal Lewis acids.