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cyclo ( β ‐Asp‐ β 3 ‐hVal‐ β 3 ‐hLys) – Solid‐Phase Synthesis and Solution Structure of a Water Soluble β ‐Tripeptide. Preliminary Communication
Author(s) -
Büttner Frank,
Erdélyi Máté,
Arvidsson Per I.
Publication year - 2004
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490246
Subject(s) - chemistry , tripeptide , side chain , aqueous solution , amide , peptide bond , stereochemistry , peptide , peptide synthesis , combinatorial chemistry , phase (matter) , water soluble , crystallography , organic chemistry , biochemistry , polymer
The H 2 O‐soluble cyclic β 3 ‐tripeptide cyclo( β ‐Asp‐ β 3 ‐hVal‐ β 3 ‐hLys) ( 4 ) was obtained by on‐resin cyclization of the side‐chain‐anchored β ‐peptide 3 ( Scheme ). In aqueous solution, 4 adopts a structure with uniformly oriented amide bonds and all side chains in lateral positions ( Fig. 3 ).