Improved Protocol for the Three‐Component  Biginelli  Reactions and  Biginelli ‐Like  Mannich  Reactions of Carbamates, Aldehydes, and Ketones | Zendy

Xu LiWen | Zendy; Wang ZongTing | Zendy; Xia ChunGu | Zendy; Li Lyi | Zendy; Zhao PeiQing | Zendy

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Improved Protocol for the Three‐Component Biginelli Reactions and Biginelli ‐Like Mannich Reactions of Carbamates, Aldehydes, and Ketones

Author(s) -

Xu LiWen,

Wang ZongTing,

Xia ChunGu,

Li Lyi,

Zhao PeiQing

Publication year - 2004

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200490234

Subject(s) - chemistry , biginelli reaction , mannich reaction , component (thermodynamics) , organic chemistry , catalysis , combinatorial chemistry , physics , thermodynamics

A mild, convenient, and improved method for the direct three‐component Biginelli and Biginelli ‐like Mannich ‐type reactions of carbonyl compounds in the presence of inexpensive FeCl 3 ⋅6 H 2 O and Me 3 SiCl as catalysts is described. Reactions performed with carbamates can be used to directly access N ‐protected β ‐amino carbonyl compounds in a single step.

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