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Improved Protocol for the Three‐Component Biginelli Reactions and Biginelli ‐Like Mannich Reactions of Carbamates, Aldehydes, and Ketones
Author(s) -
Xu LiWen,
Wang ZongTing,
Xia ChunGu,
Li Lyi,
Zhao PeiQing
Publication year - 2004
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490234
Subject(s) - chemistry , biginelli reaction , mannich reaction , component (thermodynamics) , organic chemistry , catalysis , combinatorial chemistry , physics , thermodynamics
A mild, convenient, and improved method for the direct three‐component Biginelli and Biginelli ‐like Mannich ‐type reactions of carbonyl compounds in the presence of inexpensive FeCl 3 ⋅6 H 2 O and Me 3 SiCl as catalysts is described. Reactions performed with carbamates can be used to directly access N ‐protected β ‐amino carbonyl compounds in a single step.