Cytotoxic Isoprenylated Flavonoids from the Roots of  Sophora flavescens | Zendy

Ding Peilan | Zendy; Chen Daofeng | Zendy; Bastow Kenneth F. | Zendy; Nyarko Alexander K. | Zendy; Wang Xihong | Zendy; Lee KuoHsiung | Zendy

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Cytotoxic Isoprenylated Flavonoids from the Roots of Sophora flavescens

Author(s) -

Ding Peilan,

Chen Daofeng,

Bastow Kenneth F.,

Nyarko Alexander K.,

Wang Xihong,

Lee KuoHsiung

Publication year - 2004

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200490230

Subject(s) - chemistry , sophora flavescens , cytotoxic t cell , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , cell culture , epidermoid carcinoma , traditional medicine , carcinoma , biochemistry , in vitro , medicine , matrine , chromatography , biology , genetics

Three new flavonoids, which are isoprenylated by fused 2,2‐dimethyl‐3,4‐dihydro‐2 H ‐pyran moieties, were isolated from the roots of Sophora flavescens and named flavenochromanes A–C ( 1 – 3 ). Their structures were elucidated by spectroscopic methods, including 2D‐NMR techniques. Flavenochromane C ( 3 ) showed strong cytotoxic activity against A549 (lung carcinoma), 1A9 (ovarian carcinoma), KB (epidermoid carcinoma of the nasopharynx), and KB‐Vin (drug‐resistant variant KB) cell lines with IC 50 values ≤1.7 μ M , and significant activity against the MCF‐7 (breast adenocarcinoma) cell line with an IC 50 value of 3.6 μ M . Flavenochromane B ( 2 ) displayed slightly lower inhibitory effects ( IC 50 3.2–6.9 μ M ) as compared with 3 .

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