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On the Structure of PHB (=Poly[( R )‐3‐hydroxybutanoic Acid]) in Phospholipid Bilayers: Preparation of Trifluoromethyl‐Labeled Oligo[( R )‐3‐hydroxybutanoic Acid] Derivatives
Author(s) -
Rueping Magnus,
Albert Matthias,
Seebach Dieter
Publication year - 2004
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490222
Subject(s) - chemistry , phospholipid , fluorescence , membrane , stereochemistry , crystallography , biochemistry , physics , quantum mechanics
Oligomers of ( R )‐3‐hydroxybutanoate (OHB) have previously been shown to transport cations through lipid bilayers. The ion‐transport activity has been attributed to the formation of hydrophobic aggregates or pores, which have been identified by fluorescence‐microscopy measurements of membrane‐incorporated fluorescence‐labeled OHBs. To obtain more information about these aggregates, we describe here the synthesis of the specifically F‐labeled HB oligomers II – IV for structural investigation by means of solid‐state 19 F‐NMR spectroscopic techniques.