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Stereospecific Synthesis of Carbanucleotides Designed for Antisense Methodology
Author(s) -
Zhu XueFeng,
Nydegger Freddy,
Gossauer Albert
Publication year - 2004
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490202
Subject(s) - stereospecificity , chemistry , oligonucleotide , optically active , combinatorial chemistry , stereochemistry , molecule , polymer , organic chemistry , dna , biochemistry , catalysis
A short stereospecific synthesis of the carbocyclic 2′‐deoxynucleoside analogues 36 and 37 ( Schemes 2 and 5 ) and 45 and 46 ( Schemes 2 and 6 ) starting from optically active 8,9,10‐trinorborn‐5‐en‐2‐one ( 1 ) is described. As two functional groups capable to react with each other are present in the same molecule of the synthetic carbanucleosides, the latter can form polymers similar to oligonucleotides.