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Berchemins A and B: Novel Enzyme‐Inhibiting Dimeric Lignan Glycosides from Berchemia pakistanica
Author(s) -
Mukhtar Naveen,
Malik Abdul,
Iqbal Kiran,
Tareen Rasool Bakhsh,
Khan Shamsun Nahar,
Nawaz Sarfraz Ahmad,
Choudhary M. Iqbal
Publication year - 2004
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490183
Subject(s) - chemistry , lignan , glycoside , stereochemistry , glucoside , phytochemical , enzyme , organic chemistry , biochemistry , medicine , alternative medicine , pathology
Phytochemical investigation of Berchemia pakistanica by extensive bioassay‐guided fractionation resulted in the isolation of two novel dimeric lignan glycosides, berchemin A ( 1 ) and berchemin B ( 2 ), and of the four known compounds β ‐sitosterol, β ‐sitosterol 3‐ O ‐ β ‐ D ‐glucoside, vavain, and daphnetin 8‐ β ‐ D ‐glucoside. The structures of 1 and 2 were elucidated with the help of modern spectroscopic techniques, and the known compounds were identified by comparing their spectral data with those reported in the literature. Berchemins A and B were found to inhibit lipoxygenase and α ‐glucosidase enzymes in a concentration‐dependent fashion.