An Effective and Convenient Method for the Preparation of  KAD‐1229 | Zendy

Liu Jianchao | Zendy; Yang Yushe | Zendy; Ji Ruyun | Zendy

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An Effective and Convenient Method for the Preparation of KAD‐1229

Author(s) -

Liu Jianchao,

Yang Yushe,

Ji Ruyun

Publication year - 2004

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200490174

Subject(s) - chemistry , yield (engineering) , alkylation , product (mathematics) , combinatorial chemistry , key (lock) , chiral auxiliary , organic chemistry , enantioselective synthesis , catalysis , metallurgy , computer science , materials science , geometry , mathematics , computer security

A new convenient method for the asymmetric synthesis of the potent hypoglycemic agent KAD‐1229 was developed. The key step of this method is diasteroselective alkylation of 1 to give crude 2 (d.e.>93%) in good yield with the easily available Oppolzer 's camphorsultam as chiral auxiliary. The overall yield of the product was 57%.

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