Premium
An Effective and Convenient Method for the Preparation of KAD‐1229
Author(s) -
Liu Jianchao,
Yang Yushe,
Ji Ruyun
Publication year - 2004
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490174
Subject(s) - chemistry , yield (engineering) , alkylation , product (mathematics) , combinatorial chemistry , key (lock) , chiral auxiliary , organic chemistry , enantioselective synthesis , catalysis , metallurgy , computer science , materials science , geometry , mathematics , computer security
A new convenient method for the asymmetric synthesis of the potent hypoglycemic agent KAD‐1229 was developed. The key step of this method is diasteroselective alkylation of 1 to give crude 2 (d.e.>93%) in good yield with the easily available Oppolzer 's camphorsultam as chiral auxiliary. The overall yield of the product was 57%.