Synthesis of 2‐Aryl‐ and 2‐Heteroaryl‐3,5‐dimethoxy‐1,4‐benzoquinones Involving Pd‐Catalyzed Cross‐Coupling of (2,3,4,6‐Tetramethoxyphenyl)boronic Acid | Zendy

Leão Lana Enio José | Zendy; Carazza Fernando | Zendy; Aparacida de Oliveira Rosilene | Zendy

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Synthesis of 2‐Aryl‐ and 2‐Heteroaryl‐3,5‐dimethoxy‐1,4‐benzoquinones Involving Pd‐Catalyzed Cross‐Coupling of (2,3,4,6‐Tetramethoxyphenyl)boronic Acid

Author(s) -

Leão Lana Enio José,

Carazza Fernando,

Aparacida de Oliveira Rosilene

Publication year - 2004

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200490162

Subject(s) - chemistry , aryl , boronic acid , catalysis , combinatorial chemistry , palladium , coupling (piping) , suzuki reaction , coupling reaction , medicinal chemistry , stereochemistry , organic chemistry , mechanical engineering , alkyl , engineering

A series of 2‐aryl‐ and 2‐heteroaryl‐substituted 3,5‐dimethoxy‐1,4‐benzoquinones (compounds 27 – 36 ) have been synthesized by cross‐coupling of (2,3,4,6‐tetramethoxyphenyl)boronic acid ( 2 ) with aromatic bromides or iodides in the presence of [Pd 0 (Ph 3 ) 4 ] and Na 2 CO 3 , followed by AgO‐promoted oxidation of the resulting biaryl compounds 17 – 26 .

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