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Studies on the Synthesis of Di‐ and Trisaccharide Analogues of Moenomycin A. Modifications in Unit E and in the Lipid Part
Author(s) -
Yang Guangbin,
Mansourova Madina,
Hennig Lothar,
Findeisen Matthias,
Oehme Ramona,
Giesa Sabine,
Welzel Peter
Publication year - 2004
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490161
Subject(s) - chemistry , trisaccharide , stereochemistry , mode of action , sugar , component (thermodynamics) , unit (ring theory) , combinatorial chemistry , biochemistry , physics , mathematics education , mathematics , thermodynamics
Routes allowing the synthesis of moenomycin analogues with one modified sugar component and with new lipid parts were developed (see 10c, 12c, 16b , and 20b in Schemes 2 – 4 ). It is anticipated that such analogues will be useful for studying the mode of action of the moenomycin‐type transglycosylase inhibitors in detail and for preparing analogues with improved pharmacokinetic properties.