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New ent ‐Abietanoids from Isodon rubescens
Author(s) -
Han QuanBin,
Li RongTao,
Zhang JiXia,
Sun HanDong
Publication year - 2004
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490072
Subject(s) - abietane , chemistry , terpenoid , diterpene , stereochemistry , cytotoxicity , genus , terpene , tumor cells , traditional medicine , botany , in vitro , biochemistry , cancer research , biology , medicine
Six new ent ‐abietane diterpenoids, rubescensins I–M ( 1 – 5 ) and P ( 6 ), along with two related acetonide derivatives ( 7 and 8 ), were isolated from Isodon rubescens. Their structures were elucidated by detailed spectroscopic analysis. Compound 5 is the first N‐containing diterpenoid from the genus Isodon , exhibiting notable cytotoxicity against human tumor K562 cells.
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