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Four New Diterpenoids from Ballota limbata
Author(s) -
Ahmad Viqar Uddin,
Farooq Umar,
Abbaskhan Ahmed,
Hussain Javid,
Abbasi Muhammad Athar,
Nawaz Sarfraz Ahmad,
Choudhary M. Iqbal
Publication year - 2004
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490064
Subject(s) - chemistry , moiety , stereochemistry , diterpene , genus , terpene , botany , biology
Six diterpenoids ( 1 – 6 ) belonging to the clerodane and tetracyclic diterpene types were isolated from the CHCl 3 extract of Ballota limbata. The structures of the new compounds 1 and 4 – 6 (named ballatenolide A and limbatenolides A–C, resp.) were established by their spectral data, and their relative configuration was determined by 2D NMR. Compounds 2 and 3 were identified as known clerodanes. Compound 1 had a unique feature, i.e. , an α , β ‐unsaturated γ ‐lactone moiety at C(4)/C(6), whereas limbatenolides A–C ( 4 – 6 ) belonged to the rare class of tetracyclic diterpenoids, which are known to occur only in the genus Ballota. All of the isolated compounds showed inhibitory potential in a cholinesterase‐inhibition assay.