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Bioactive Chemical Constituents of Cladiella Species
Author(s) -
Ata Athar,
Ackerman Joe,
Bayoud Abdelhamid,
Radhika Parvataneni
Publication year - 2004
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200490056
Subject(s) - chemistry , sesquiterpene , antibacterial activity , pseudomonas aeruginosa , escherichia coli , streptococcus pyogenes , stereochemistry , acetylcholinesterase , staphylococcus aureus , bacteria , organic chemistry , biochemistry , enzyme , genetics , gene , biology
From the methanolic extract of Cladiella sp., collected from the Andaman Island, India, a new sesquiterpene, cladidiol ( 2 ), and three known diterpenes, cladiellaperoxide ( 3 ), (6 E )‐2 α ,9 α ‐epoxyeunicella‐6,11(12)‐dien‐3 β ‐ol ( 4 ), and polyanthellin A ( 5 ) were isolated. The structures of these compounds were established by extensive spectroscopic studies. Compound 2 exhibited modest acetylcholinesterase‐inhibition activity, and compounds 3 – 5 showed antibacterial activities against Streptococcus pyogenes, Escherichia coli , and Pseudomonas aeruginosa.