Spiromarienonols A and B: Two New 7(8→9) abeo ‐Lanostane‐Type Triterpene Lactones from the Stem Bark of  Abies mariesii | Zendy

Tanaka Reiko | Zendy; Wada Shunichi | Zendy; Aoki Hitoshi | Zendy; Matsunaga Shunyo | Zendy; Yamori Takao | Zendy

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Spiromarienonols A and B: Two New 7(8→9) abeo ‐Lanostane‐Type Triterpene Lactones from the Stem Bark of Abies mariesii

Author(s) -

Tanaka Reiko,

Wada Shunichi,

Aoki Hitoshi,

Matsunaga Shunyo,

Yamori Takao

Publication year - 2004

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200490011

Subject(s) - triterpene , lanostane , pinaceae , chemistry , bark (sound) , stereochemistry , terpene , botany , pinus <genus> , biology , medicine , ecology , alternative medicine , pathology

Two new skeletal triterpene lactones, spiromarienonols A ( 1a ) and B ( 2a ), were isolated from the stem bark of Abies mariesii Masters (Pinaceae). Based on spectral data and biogenetic considerations, their unique three‐dimensional structures were determined to be (3 R ,7 S ,9 R ,23 R )‐ ( 1a ) and (3 R ,7 S ,9 S ,23 R )‐3,7‐dihydroxy‐8‐oxo‐7(8→9) abeo ‐lanost‐24‐eno‐26,23‐lactone ( 2a ). Moreover, the potent activity of abiesenonic acid methyl ester ( 3 ) and abieslactone ( 4 ) against a disease‐oriented panel of 39 human cancer cell lines were investigated.

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