Bauhinoxepins A and B: New Antimycobacterial Dibenzo[ b , f ]oxepins from  Bauhinia saccocalyx | Zendy

Kittakoop Prasat | Zendy; Nopichai Sombat | Zendy; Thongon Nuntawan | Zendy; Charoenchai Panarat | Zendy; Thebtarath Yodhathai | Zendy

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Bauhinoxepins A and B: New Antimycobacterial Dibenzo[ b , f ]oxepins from Bauhinia saccocalyx

Author(s) -

Kittakoop Prasat,

Nopichai Sombat,

Thongon Nuntawan,

Charoenchai Panarat,

Thebtarath Yodhathai

Publication year - 2004

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200490006

Subject(s) - antimycobacterial , chemistry , stereochemistry , diol , bauhinia , anti malarial , traditional medicine , malaria , organic chemistry , mycobacterium tuberculosis , tuberculosis , plasmodium falciparum , biology , immunology , medicine , pathology

Two new antimycobacterial dibenzo[ b , f ]oxepins, bauhinoxepins A (=3,3,5‐trimethylbenzo[ b ]pyrano[ g ][1]benzoxepin‐6,11‐diol; 1 ) and B (=6‐methoxy‐7‐methyl‐2‐(3‐methylbut‐2‐enyl)dibenzo[ b , f ]oxepine‐1,8‐diol; 2 ), were isolated from the roots of Bauhinia saccocalyx , and their structures were elucidated by analysis of spectroscopic data. Bauhinoxepins A and B exhibited antimycobacterial activities with respective minimum‐inhibitory concentrations ( MIC ) of 6.25 and 12.5 μg/ml. They were inactive (at 20 μg/ml) against the malarial parasite, and also inactive (at 20 μg/ml) towards the Vero, KB, and BC cell lines.

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