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Pyrrolizidine Alkaloids from Onosma leptantha
Author(s) -
Kretsi Ourania,
Aligiannis Nektarios,
Skaltsounis Alexios Leandros,
Chinou Ioanna B.
Publication year - 2003
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200390254
Subject(s) - pyrrolizidine , chemistry , stereochemistry
Three new pyrrolizidine alkaloids, leptanthine ( 2 ), its corresponding N ‐oxide 1 , and N ‐oxide of 3′‐ O ‐acetylechihumiline ( 3 ), were isolated from the aerial parts of Onosma leptantha , together with two known alkaloids of the same type, echihumiline ( 5 ) and echihumiline N ‐oxide ( 4 ). Their structures and configurations were determined by chemical and spectroscopic methods, especially 1D and 2D NMR analyses, including long‐range 1 H, 15 N correlations at natural abundance.